很多自闭症的发生，都和大脑发育早期 “信号走错路”有关。越来越多研究发现，一条叫Notch的关键信号通路，在自闭症模型里常常被异常激活，就像电路一直被错误通电，导致负责大脑平衡的神经元发育出错、神经环路乱掉，最终出现社交差、重复行为、沟通异常等问题。

很多自闭症的发生，都和大脑发育早期 “信号走错路”有关。越来越多研究发现，一条叫Notch的关键信号通路，在自闭症模型里常常被异常激活，就像电路一直被错误通电，导致负责大脑平衡的神经元发育出错、神经环路乱掉，最终出现社交差、重复行为、沟通异常等问题。

While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in ...

Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...